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Biogenesis, functional roles, and pathological implications of migrasomes
Xuexue Liu1,2, Dun Liu3, Heng Zhao4
1Department of Pharmacy, Nanjing Medical Center for Clinical Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Cell Death & Disease
|August 19, 2025
Summary
Migrasomes, novel organelles involved in cell migration, facilitate intercellular communication and homeostasis. Further research into their biogenesis and functions may unlock new therapeutic applications for disease treatment.
Area of Science:
- Cell Biology
- Organelle Biology
- Intercellular Communication
Background:
- Migrasomes are newly identified organelles found at retraction fiber tips during cell migration.
- They contain vesicles and are involved in processes like intracellular homeostasis and cell-to-cell signaling.
Purpose of the Study:
- To review the biogenesis, functions, and pathological roles of migrasomes.
- To explore the therapeutic potential of migrasomes as a novel intercellular communication mechanism.
Main Methods:
- Literature review of recent research on migrasomes.
- Analysis of migrasome biogenesis and functional mechanisms.
- Discussion of pathological implications and therapeutic prospects.
Main Results:
- Migrasomes expand during cell migration, leading to retraction fiber rupture and intercellular transfer.
- They play significant roles in cellular growth, development, and maintaining homeostasis.
- Migrasomes represent a promising avenue for intercellular communication and therapeutic interventions.
Conclusions:
- Migrasomes are crucial for cellular processes and intercellular communication.
- Understanding migrasome physiology offers potential for disease diagnosis and treatment.
- Further investigation into migrasome functions is warranted for therapeutic applications.
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