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Related Experiment Videos

Polymorphism at two loci through selection for linear metric deviation.

R Linney

    Heredity
    |June 1, 1977
    PubMed
    Summary

    Stabilizing selection can maintain genetic variation through specific fitness conditions. This occurs when double heterozygotes have higher fitness than intermediate homozygotes, promoting polymorphism.

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    Variation for metrical characters in drosophila populations. 3. The nature of selection.

    Heredityยท1971
    See all related articles

    Area of Science:

    • Evolutionary genetics
    • Population genetics
    • Quantitative genetics

    Background:

    • Phenotypic stabilizing selection influences trait evolution by favoring intermediate phenotypes.
    • Understanding the genetic basis of trait variation under selection is crucial for evolutionary studies.

    Purpose of the Study:

    • To algebraically explore a model of phenotypic stabilizing selection.
    • To investigate the conditions under which genetic variation is maintained at two linked loci.

    Main Methods:

    • Algebraic analysis of a two-locus model.
    • Examination of fitness regimes and gene effects.

    Main Results:

    • Selection for metric deviation can lead to polymorphic gamete-frequency equilibria.
    • Non-trivial equilibria are stable across a broad range of parameters.
    • Close linkage and unequal gene effects facilitate stability.

    Conclusions:

    • Genetic variation can be maintained under stabilizing selection.
    • This maintenance is likely when double heterozygotes exhibit higher fitness than phenotypically intermediate homozygotes.

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