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Inflammatory markers guide early risk stratification and prognosis in elderly patients with acute myocardial

XiaoLong Lin1, Qian Fan1, QiuYu Li1

  • 1Center for Coronary Artery Disease, Beijing AnZhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.

Scientific Reports
|August 19, 2025
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) can predict adverse outcomes in elderly acute myocardial infarction (AMI) patients. Higher hs-CRP levels are linked to increased in-hospital events, establishing it as a valuable prognostic biomarker.

Area of Science:

  • Cardiology
  • Biomarkers
  • Geriatric Medicine

Background:

  • High-sensitivity C-reactive protein (hs-CRP) is a known prognostic marker in acute myocardial infarction (AMI).
  • Limited data exists on the predictive value of hs-CRP in elderly AMI patients.

Purpose of the Study:

  • To investigate the association between hs-CRP levels and in-hospital adverse events in elderly AMI patients.
  • To evaluate hs-CRP as an independent predictor of prognosis in this population.

Main Methods:

  • Retrospective analysis of 590 elderly AMI patients.
  • Stratification into three groups based on hs-CRP tertiles.
  • Multivariate logistic regression and risk model integration for predictive accuracy assessment.

Main Results:

  • Adverse in-hospital event incidence increased with higher hs-CRP tertiles (17.2% to 48%, P<0.001).
  • Elevated hs-CRP was an independent predictor of adverse outcomes (Q3: OR 2.21, P=0.008).
  • hs-CRP improved risk reclassification and discrimination when added to existing models (NRI: 0.461, IDI: 0.046).

Conclusions:

  • hs-CRP is a reliable and practical biomarker for predicting poor prognosis in elderly AMI patients.
  • The integration of hs-CRP into risk models enhances predictive capabilities for adverse events.

Keywords:
Acute myocardial infarctionElderly patientsHigh sensitivity C-reactive proteinIn hospital outcomes

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