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Log odds of positive lymph nodes as a prognostic marker in resectable triple negative breast cancer

  • 0Department of Clinical Laboratory, Shiyan Maternal and Child Health Hospital, Shiyan, 442000, China.
Scientific Reports +

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August 19, 2025

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August 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The log odds of positive lymph nodes (LODDS) is a reliable prognostic marker for triple-negative breast cancer (TNBC) survival. This marker can help personalize postoperative treatment decisions for patients with resectable, nonmetastatic TNBC.

Area Of Science

  • Oncology
  • Biostatistics
  • Surgical Oncology

Background

  • Triple-negative breast cancer (TNBC) presents unique challenges in treatment and prognosis.
  • Accurate prognostic markers are crucial for guiding postoperative management in resectable, nonmetastatic TNBC.
  • The log odds of positive lymph nodes (LODDS) is a novel metric for assessing lymph node involvement.

Purpose Of The Study

  • To evaluate the prognostic significance of LODDS in patients with resectable, nonmetastatic TNBC.
  • To determine if LODDS can inform postoperative treatment strategies.
  • To explore the association between LODDS, surgical approach, and survival outcomes.

Main Methods

  • Retrospective cohort study using SEER 17 registries (2010-2021).
  • Analysis of cancer-specific survival (CSS) using restrictive cubic splines (RCS) and propensity score matching (PSM).
  • Evaluation of surgical approaches (breast-conserving surgery vs. mastectomy) in relation to LODDS and survival.

Main Results

  • A significant nonlinear association was found between LODDS and CSS (p < 0.001).
  • A LODDS threshold of -1.6 differentiated low-risk and high-risk patients, with superior survival in the low-risk group.
  • Breast-conserving surgery (BCS) was associated with better survival than mastectomy, especially in high-risk LODDS patients. BCS with radiotherapy showed the most benefit.

Conclusions

  • LODDS is a robust prognostic indicator for survival in resectable, nonmetastatic TNBC.
  • Integrating LODDS into risk stratification can personalize postoperative management, particularly after BCS.
  • The findings support tailored treatment decisions based on LODDS and patient age.

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