Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of PET imaging of [18F]F-FAPI and [18F]F-FDG for diagnosis of suspected lymph node metastases in penile squamous cell carcinoma: a prospective pilot study.

European journal of nuclear medicine and molecular imaging·2026

Same author

Precise Synergistic Photoregulation of Dual-Target Gene Expression by Engineering Caged Two-in-One DNA-RNA Nanoframework Based on Near-Infrared Light Uncaging Strategy.

Advanced healthcare materials·2026

Same author

Naomaili Granules Attenuate Cerebral Ischemia/Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress and RhoA/Pyrin Signaling Pathway.

Rejuvenation research·2025

Same author

The role of loneliness and self-concept clarity in the relationship between problematic mobile social network usage and social anxiety among college students.

Frontiers in psychology·2025

Same author

Peptide-conjugated fluorescent molecular rotor for subcellular protein detection.

Nanoscale·2025

Same author

Nanopore-confined photosensitizer in metal-organic frameworks enable enhanced multi-responsive photodynamic activities for efficient tumor cell elimination.

Journal of colloid and interface science·2025

Search research articles

Related Experiment Video

Updated: Sep 10, 2025

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Automated Preparation of [⁶⁸Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

[18F]F-FAPI PET/CT outperforms [18F]F-FDG PET/CT in predicting treatment response in lupus nephritis.

Min Zhao¹, Chunqing Zhou¹, Hao Fang¹

¹Department of Nuclear Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.

European Journal of Nuclear Medicine and Molecular Imaging

|August 19, 2025

Summary

[18F]F-FAPI PET/CT imaging is a superior predictor of treatment success in lupus nephritis (LN) compared to [18F]F-FDG PET/CT. This noninvasive biomarker can help guide personalized therapy for LN patients.

Keywords:

Fibroblast activation Imaging biomarker Lupus nephritis PET/CT Treatment response

More Related Videos

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Related Experiment Videos

Last Updated: Sep 10, 2025

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Automated Preparation of [⁶⁸Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

Nuclear Medicine
Radiopharmacology
Nephrology

Background:

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus, necessitating effective treatment monitoring.
Predicting short-term treatment response in LN is crucial for timely therapeutic adjustments.
Novel imaging biomarkers are needed to noninvasively assess treatment efficacy in LN.

Purpose of the Study:

To identify predictors of complete response (CR) after induction therapy in lupus nephritis (LN).
To compare the predictive value of baseline [18F]F-FAPI PET/CT versus [18F]F-FDG PET/CT for short-term treatment outcomes in LN.

Main Methods:

Twenty biopsy-proven LN patients prospectively underwent dual-tracer PET/CT imaging ([18F]F-FAPI and [18F]F-FDG) before induction therapy.
Treatment response (CR, partial response [PR], non-response [NR]) was assessed at 6 months.
Semiquantitative PET parameters (SUVmax, TBR) and clinical biomarkers were analyzed for associations with treatment response.

Main Results:

Baseline renal [18F]F-FAPI SUVmax correlated inversely with eGFR and positively with ESR.
Patients achieving CR had significantly lower baseline renal [18F]F-FAPI SUVmax and TBR compared to non-CR patients.
[18F]F-FAPI PET/CT demonstrated higher accuracy (85%), specificity (90%), and PPV (89%) than [18F]F-FDG PET/CT in predicting CR.

Conclusions:

[18F]F-FAPI PET/CT shows superior predictive performance for short-term treatment response in LN compared to [18F]F-FDG PET/CT.
Negative baseline [18F]F-FAPI uptake is an independent predictor of CR in LN.
[18F]F-FAPI PET/CT holds promise as a noninvasive biomarker for guiding LN treatment decisions.