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Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
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Master Protocols: A Promising Approach to Accelerate Drug Development in Rare Kidney Diseases

Julie Lin1, Jai Radhakrishnan2

  • 1Sanofi, Cambridge, MA and Brigham and Women's Hospital, MRB-4, 75 Francis Street, Boston, MA, USA. julierenal@gmail.com.

Therapeutic Innovation & Regulatory Science
|August 20, 2025
PubMed

Insights

Drug development for kidney diseases is advancing with new surrogate endpoints. Proteinuria reduction and slowing estimated glomerular filtration rate decline are accelerating clinical trials and investment.

Area of Science:

  • Nephrology and drug development.
  • Advancements in clinical trial design for kidney diseases.

Background:

  • Traditional kidney disease drug development faced hurdles due to lengthy clinical trial endpoints like dialysis or transplantation.
  • These lengthy trials required significant time and participant numbers, hindering therapeutic innovation.

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