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Flavonoids Being Chemo-Preventive Agents Induce Programmed Cell Death: Mechanisms and Therapeutic Potentials
Mateen Nawaz1, Arooj Nawaz2, Muhammad Nadeem Khan3
1Department of Pharmacology, Shantou University Medical College, Shantou, China.
Phytotherapy Research : PTR
|August 20, 2025
Summary
Flavonoids, natural compounds with antioxidant properties, can prevent cancer by initiating programmed cell death (PCD) pathways. Understanding these mechanisms can lead to new cancer therapies.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Flavonoids exhibit chemo-preventive properties against cancer.
- Their mechanisms involve antioxidant effects, proliferation limitation, angiogenesis suppression, and immune modulation.
- Flavonoids activate various Programmed Cell Death (PCD) pathways, crucial in disease treatment.
Purpose of the Study:
- To provide a comprehensive overview of PCD.
- To detail the impact of flavonoids on initiating diverse PCD pathways.
- To explore flavonoid mechanisms in cancer prevention and PCD pathway elucidation.
Main Methods:
- Literature review of programmed cell death.
- Analysis of flavonoid interactions with cellular death pathways.
- Examination of preclinical and clinical studies on PCD-targeting drugs.
Main Results:
- Flavonoids possess significant potential in cancer chemo-prevention.
- They activate multiple PCD pathways, offering therapeutic strategies.
- Understanding these pathways aids in developing novel cancer treatments.
Conclusions:
- Flavonoids are promising agents for cancer therapy through PCD induction.
- Further research into flavonoid-PCD interactions can overcome drug resistance.
- This knowledge can guide the development of new therapeutic regimens for cancer.
Keywords:
PANaptosisapoptosisautophagycuproptosisdisulfidoptosisferroptosisflavonoidsnecrosptosispyroptosisMore Related Videos
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