Related Experiment Video

Updated: Sep 10, 2025

Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet
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Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet

Published on: November 2, 2020

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Treatment of Clinically Important Bacteria With Cold Atmospheric Plasma

Ruolan Ding1, Jiajun Song2, Xiaonan Huang3

  • 1Department of Microbiology, School of Medicine, Chongqing University, Chongqing, China.

Microbial Biotechnology
|August 20, 2025
PubMed

Insights

Cold atmospheric plasma (CAP) offers a novel disinfection method to combat antimicrobial resistance (AMR). This review explores CAP

Area of Science:

  • Microbiology
  • Plasma Physics
  • Biomedical Engineering

Background:

  • Antimicrobial resistance (AMR) presents a significant global health threat, necessitating novel therapeutic strategies.
  • Traditional antibiotics are becoming less effective against increasingly resistant bacterial strains.
  • Cold atmospheric plasma (CAP) has emerged as a promising new technology for microbial disinfection.

Purpose of the Study:

  • To review the generation and disinfection mechanisms of CAP.
  • To summarize the applications of CAP against clinically significant Gram-positive and Gram-negative bacteria.
  • To discuss strategies for enhancing CAP efficacy and safety for potential clinical use.

Main Methods:

  • Review of existing literature on CAP generation and its interaction with bacterial cells.
  • Compilation of studies detailing CAP's effectiveness against various bacterial pathogens.
  • Analysis of technological advancements aimed at improving CAP disinfection capabilities.

Main Results:

  • CAP utilizes reactive species in ionized gas to effectively kill bacteria.
  • CAP demonstrates efficacy against a broad spectrum of bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
  • Strategies exist to optimize CAP's disinfection power and ensure its safety for biological applications.

Conclusions:

  • Cold atmospheric plasma is a viable alternative technology for combating bacterial infections.
  • Further development of CAP-based strategies holds potential for overcoming the challenges posed by antimicrobial resistance.
  • This review provides a comprehensive overview to guide future research and development in CAP applications for AMR.
Keywords:
antibiotic‐resistance bacteriabactericidal mechanismscold atmospheric plasmainfectious disease controlsynergistic antimicrobial strategy

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