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Targeting Posttranslational Modifications in the Tumor Stromal Microenvironment for Antitumor Therapy
Huiguo Qing1,2,3, Xiangyan Jiang1,2,3, Yong Ma1,2,3
1Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.
Molecular Carcinogenesis
|August 20, 2025
Summary
Posttranslational modifications (PTMs) regulate the tumor microenvironment, impacting cancer progression and therapy resistance. Targeting PTMs in the tumor stroma offers a promising new direction for cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- The tumor stromal microenvironment, comprising stromal cells and extracellular matrix (ECM), significantly influences tumor malignancy and resistance to therapies.
- Signaling pathways, metabolic regulation, and cell cycle dynamics are key factors affecting the tumor microenvironment.
- Posttranslational modifications (PTMs) are critical regulators of protein function with established roles in cancer.
Purpose of the Study:
- To explore the regulatory role of PTMs within the tumor stromal microenvironment.
- To review recent advancements in cancer therapy targeting PTMs.
- To highlight PTMs as a novel therapeutic strategy in oncology.
Main Methods:
- Literature review of studies on PTMs and the tumor microenvironment.
- Analysis of PTMs' impact on stromal cell behavior, signal transduction, and ECM remodeling.
- Examination of current and emerging cancer therapies focused on PTMs.
Main Results:
- PTMs modulate various aspects of the tumor stromal microenvironment, including cell behavior and ECM composition.
- PTMs are implicated in tumor initiation, progression, metastasis, and the development of therapy resistance.
- Targeting PTMs influences stromal components crucial for tumor growth and survival.
Conclusions:
- PTMs play a significant regulatory role in the tumor stromal microenvironment.
- Modulating PTMs in the tumor stroma presents a promising avenue for novel cancer therapies.
- Targeting PTMs offers a new strategic direction for improving cancer treatment outcomes.
Keywords:
antitumor therapycollagen depositionextracellular matrixposttranslational modificationstumor stromal microenvironmentMore Related Videos
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