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Updated: Sep 10, 2025

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
Published on: February 28, 2020
Targeting Posttranslational Modifications in the Tumor Stromal Microenvironment for Antitumor Therapy
Huiguo Qing1,2,3, Xiangyan Jiang1,2,3, Yong Ma1,2,3
1Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.
None:
The stromal microenvironment of tumors, comprised of diverse stromal cells and extracellular matrix (ECM), is intricately influenced by multiple signaling pathways, metabolic regulation, and the cell cycle, significantly contributing to tumor malignancy and therapy resistance. Posttranslational modifications (PTMs), crucial mechanisms for regulating protein function in organisms, engage in tumor initiation, progression, metastasis, and therapy resistance by modulating stromal cell behavior, stromal signal transduction, ECM deposition, and remodeling within the tumor stromal microenvironment. This article explores the regulatory role of PTMs within the tumor stromal microenvironment and reviews recent advancements in cancer therapy focused on PTMs. Targeting PTMs within the tumor stromal microenvironment shows promising potential as a novel approach and direction in cancer treatment.
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