Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

7.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.6K
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

1.7K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.7K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

891
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
891

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SynTME: A tumor microenvironment-aware, pharmacology-inspired multi-stage framework for drug synergy prediction.

Computer methods and programs in biomedicine·2026
Same author

Enhanced nitrogen and phosphorus removal from mining-affected waters by micro-nano aeration coupled with microbial remediation.

Environmental technology·2026
Same author

Comparative analysis of four nutritional scores in predicting hospital stay duration for EICU Patients with acute pancreatitis.

Frontiers in nutrition·2026
Same author

A TaKNOX1-TaAPO1-Rht1 feedback regulatory module orchestrates spikelet number and yield potential in wheat.

Plant communications·2026
Same author

In Situ Construction of Superhydrophobic Photothermal Coatings Based on Metal-Polyphenol Coordination Complex for Anti-/De-Icing Applications.

Polymers·2026
Same author

Dynamics of H3K4me3 and H3K36me3 histone modifications in response to powdery mildew infection in common wheat.

BMC plant biology·2026

Related Experiment Video

Updated: Apr 28, 2026

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

10.4K

IR808-ATIPA: A Dual-Function Agent for Enhanced Computed Tomography Imaging and Radiotherapy Sensitization in

Kejin Liu1,2, Rourou Zuo1,2, Zhe Wang3

  • 1Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang, China.

Biomaterials Research
|August 20, 2025
PubMed
Summary

A novel iodine-based compound, IR808-ATIPA, improves computed tomography (CT) imaging and enhances radiotherapy for cervical cancer by promoting ferroptosis. This theranostic agent offers precise tumor delineation and targeted treatment with minimal side effects.

More Related Videos

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.2K
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.5K

Related Experiment Videos

Last Updated: Apr 28, 2026

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

10.4K
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.2K
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.5K

Area of Science:

  • Biomedical Engineering
  • Radiology
  • Oncology

Background:

  • Radiotherapy is crucial for localized cancer treatment but faces challenges in balancing efficacy and collateral damage.
  • Conventional iodinated contrast agents have limitations in metabolism and imaging windows, impacting radiotherapy planning.
  • Precise tumor delineation and targeted radiosensitization are needed to improve treatment outcomes.

Purpose of the Study:

  • To develop and evaluate IR808-ATIPA, a novel iodine-based compound for computed tomography (CT) imaging and radiosensitization.
  • To assess the theranostic potential of IR808-ATIPA in enhancing radiotherapy efficacy for cervical cancer.
  • To investigate the mechanism of action and safety profile of IR808-ATIPA.

Main Methods:

  • Synthesis of IR808-ATIPA by covalently linking IR808 and ATIPA.
  • In vitro and in vivo evaluations in HeLa tumor-bearing nude mice for imaging performance and tumor retention.
  • RNA sequencing to elucidate the mechanism of radiosensitization, focusing on ferroptosis pathway activation.
  • Safety assessments to evaluate organ toxicity.

Main Results:

  • IR808-ATIPA demonstrated superior in vitro/in vivo CT imaging performance with prolonged tumor retention.
  • The compound enhanced radiotherapy efficacy by activating ferroptosis through increased reactive oxygen species and amplified X-ray absorption.
  • Safety assessments revealed no significant toxicity in major organs.

Conclusions:

  • IR808-ATIPA acts as a dual-function theranostic agent for precise tumor delineation and ferroptosis-mediated radiotherapy enhancement.
  • Its extended intratumoral retention enables targeted therapy, minimizing off-target effects.
  • IR808-ATIPA shows promise for advancing personalized cancer treatment through imaging-guided precision and improved therapeutic efficacy.