Related Experiment Video
Updated: Sep 8, 2025
Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
Published on: January 24, 2025
From Treatment to Trigger: Steroid-Induced Pancreatitis in the Setting of Leukocytoclastic Vasculitis
Yasasvhinie Santharam1, Ty J Merry1, Alexis M Chrystman1
1Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Abstract:
Steroid-induced pancreatitis (SIP) is a relatively uncommon diagnosis, as the main function of glucocorticoids is to decrease cellular inflammation and modulate the immune system. It is a diagnosis of exclusion with a multifactorial pathophysiology and can occur in the setting of treatment with steroids for various underlying conditions. While difficult to diagnose, it can cause patients great discomfort and lead to several complications if missed or treated inappropriately. We seek to highlight a case of SIP in a patient with leukocytoclastic vasculitis who was treated with intravenous and oral steroid therapy, with a clear progression of her pancreatitis seen in serial abdominal imaging.
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...