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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

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Published on: September 13, 2018

Clade Ib Mpox Virus: How Can We Respond?

Lin Ai¹, Xinyi Cui², Yanqiu Zhou¹

¹Institute of Microbiology Laboratory, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.

China CDC Weekly

|August 20, 2025

Summary

Mpox virus Clade Ib, first identified in 2023, is a growing global health concern due to its rapid spread and severe outcomes. This review covers its characteristics, spread, and control strategies.

Keywords:

Clade Ib MPXV mpox virus

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Area of Science:

* Virology and Epidemiology
* Public Health and Infectious Diseases

Background:

* Mpox virus Clade Ib emerged in the Democratic Republic of the Congo in September 2023.
* Rapid international spread to 12 non-African countries documented by July 2024.
* Clade Ib presents increased transmissibility and risk of severe illness, particularly in vulnerable populations.

Purpose of the Study:

* To provide a comprehensive overview of mpox virus Clade Ib.
* To detail its genetic features, epidemiological trends, and transmission dynamics.
* To discuss current and needed prevention and control strategies.

Main Methods:

* Review of current scientific literature and epidemiological data.
* Analysis of genetic characteristics and transmission patterns.
* Synthesis of public health interventions and control measures.

Main Results:

* Clade Ib demonstrates heightened transmissibility compared to previous strains.
* Higher rates of severe mpox symptoms and mortality observed, especially in children, pregnant individuals, and immunocompromised groups.
* Primary transmission routes include sexual contact, close household contact, and healthcare exposure.

Conclusions:

* Mpox virus Clade Ib represents a significant and evolving global health threat.
* Targeted public health strategies are crucial for effective prevention and control.
* Ongoing surveillance and research are essential to manage this emerging infectious disease.