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The treatment of enteric fever with mecillinam

A M Geddes, P D Clarke

    The Journal of Antimicrobial Chemotherapy
    |July 1, 1977
    PubMed

    Insights

    Mecillinam shows high activity against Salmonella spp. Clinical studies demonstrate its efficacy in treating 13 of 15 patients with typhoid or paratyphoid fever, indicating its potential as an enteric fever antibiotic.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Salmonella spp. are significant pathogens causing enteric fever.
    • Mecillinam is an amidinopenicillanic acid antibiotic with demonstrated in vitro activity against Salmonella spp.

    Purpose of the Study:

    • To investigate the clinical efficacy of mecillinam in patients diagnosed with enteric fever.
    • To evaluate mecillinam as a treatment option for typhoid and paratyphoid fever.

    Main Methods:

    • In vitro susceptibility testing of mecillinam against Salmonella spp.
    • Clinical trial involving patients with confirmed typhoid or paratyphoid fever.

    Main Results:

    • High in vitro activity of mecillinam against Salmonella spp. was confirmed.
    • Successful treatment outcomes were observed in 13 out of 15 patients with enteric fever.

    Conclusions:

    • Mecillinam exhibits promising efficacy in treating patients with typhoid and paratyphoid fever.
    • This amidinopenicillanic acid antibiotic represents a potential new therapeutic agent for enteric fever infections.

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