Related Experiment Video
Updated: Sep 8, 2025
09:42
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
2.9K
Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke.
Jaeseob Yun1, Jae Wook Jung2, Kwang Hyun Kim3
1Department of Neurology, Keimyung University School of Medicine, Daegu, Republic of Korea.
Frontiers in Neurology
|August 20, 2025
Summary
Large ischemic stroke thrombi contain more red blood cells (RBCs) and exhibit a mixed pattern. Increased RBCs contribute to thrombus growth and fragmentation, potentially guiding endovascular therapy (EVT) strategies.
Area of Science:
- Neurology
- Pathology
- Medical Imaging
Background:
- Thrombus burden significantly influences ischemic stroke presentation and outcomes.
- The relationship between thrombus volume and its histological composition remains underexplored.
- Understanding this relationship is crucial for optimizing stroke treatment.
Purpose of the Study:
- To investigate if thrombus composition and spatial distribution patterns in ischemic stroke differ based on thrombus volume.
- To analyze the association between thrombus volume, histopathology, and distribution patterns.
- To explore the correlation with clinical and radiologic outcomes.
Main Methods:
- Patients undergoing endovascular therapy (EVT) for thrombi were enrolled.
- Thrombus volume was measured using 3D software on CT scans.
- Immunohistochemistry analyzed fibrin, red blood cells (RBCs), and platelets; thrombi were classified by distribution patterns.
Main Results:
- Increased thrombus volume correlated with higher RBC proportion and lower platelet proportion.
- Thrombus volume was independently associated with RBC proportion and mixed/erythrocytic patterns.
- Higher thrombus volume and RBC proportion were linked to increased thrombus fragmentation during EVT.
Conclusions:
- Larger thrombi are characterized by increased RBC proportions and a mixed distribution pattern.
- RBC incorporation is a key factor in thrombus volumetric growth and fragmentation susceptibility.
- These findings may inform tailored EVT strategies for ischemic stroke patients.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
40
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
40
01:29Venous Thrombosis III: Interprofessional Care
22
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
33
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
33
01:16Clot Retraction and Fibrinolysis
6.8K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.8K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
888
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
888
01:22Formation of the Platelet Plug
7.0K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.0K