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Significance of Pulmonary Vascular Dysfunction in Chronic Obstructive Pulmonary Disease
Steven D Nathan1, Lucilla Piccari2, Steven H Abman3
1Advanced Lung Disease and Transplant Program Inova Schar Heart and Vascular Institute Falls Church Virginia USA.
Pulmonary vascular dysfunction is common in chronic obstructive pulmonary disease (COPD), often underdiagnosed. Increased research and clinical trials are needed to address this significant unmet need in COPD management.
Area of Science:
- Cardiovascular Medicine
- Respiratory Medicine
- Pulmonary Hypertension
Background:
- Chronic obstructive pulmonary disease (COPD) is frequently associated with pulmonary vascular abnormalities.
- These abnormalities range from mild dysfunction to severe pulmonary hypertension.
- The impact of pulmonary vascular dysfunction in COPD is likely underestimated globally.
Purpose of the Study:
- To highlight the role of the pulmonary vasculature in COPD.
- To increase awareness of pulmonary vascular dysfunction in COPD.
- To stimulate further research and clinical trials.
Main Methods:
- Deliberations of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative (PVRI IDDI) Group 3 Pulmonary Hypertension Workstream.
- Review of existing knowledge on pulmonary vasculature in COPD.
- Identification of unmet needs in research and treatment.
Main Results:
- Pulmonary vascular abnormalities are a significant, underappreciated comorbidity in COPD.
- There is a spectrum of vascular dysfunction, including pulmonary hypertension.
- Limited resources in many regions hinder accurate assessment of the problem.
Conclusions:
- Pulmonary vascular dysfunction is a critical aspect of COPD.
- Increased research, including clinical trials, is essential.
- Addressing this unmet need can improve COPD patient outcomes.
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