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Discovery of a Small Molecule TREM2 Agonist with Improved In Vitro Pharmacokinetic Profile and Validated Target

Shaoren Yuan1, Farida El Gaamouch1, Sungwoo Cho1

  • 1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States.

ACS Medicinal Chemistry Letters
|August 20, 2025
PubMed

Keywords:
Alzheimer’s diseaseTREM2computational chemistrydrug discoverypharmacokinetics

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