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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Structure-Activity Relationships and Drug Design01:28

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
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Pharmacovigilance01:19

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
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Maximizing Potential: Academic-Industry Collaborations in Drug Discovery.

Susan Winks1, Jutta Reinhard-Rupp2, Kelly Chibale1,2,3

  • 1Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.

ACS Medicinal Chemistry Letters
|August 20, 2025
PubMed
Summary
This summary is machine-generated.

Academic-industry partnerships accelerate pharmaceutical innovation. This exploration details the advantages and hurdles of these collaborations in drug discovery.

Keywords:
Academic−Industry CollaborationDrug DiscoveryPublic−Private PartnershipTranslational Research

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Area of Science:

  • Pharmaceutical Science
  • Biotechnology
  • Drug Discovery

Background:

  • Academic-industry collaborations are vital for advancing pharmaceutical innovation.
  • These partnerships are particularly crucial in drug discovery due to its complex, costly, and high-risk nature.

Purpose of the Study:

  • To explore the benefits and challenges of academic-industry collaborations in pharmaceutical research.
  • To provide insights based on direct experience with such partnerships.

Main Methods:

  • Qualitative analysis of direct experiences within academic-industry collaborations.
  • Case study approach examining collaborative projects (details not specified in abstract).

Main Results:

  • Identification of key benefits, such as shared expertise and resources.
  • Identification of key challenges, including intellectual property and communication barriers (details not specified in abstract).

Conclusions:

  • Academic-industry collaborations offer significant potential for pharmaceutical innovation.
  • Addressing the challenges is crucial for maximizing the success of these partnerships.