Efficacy and Safety of Radiofrequency and Focused Ultrasound in Facial Rejuvenation: A Single-Center, Single-Blind,...

Although both radiofrequency (RF) and focused ultrasound (FU) are commonly used non-invasive skin-tightening methods, comparative studies between the two methods are lacking.

To study and compare the efficacy and safety of RF and FU in facial rejuvenation.

We recruited 36 patients to receive a single treatment: the RF group (n = 21) and the FU group (n = 15). Every participant was evaluated on baseline (T0), 1-month follow-up (T1) and 3-month follow-up (T3). Three blinded dermatologists used the FLR scale, Modified Fitzpatrick Wrinkle Scale (MFWS), and Allergan Skin Roughness Scale to assess facial wrinkles. Safety profiles were recorded, and subjects completed questionnaires to provide subjective evaluations.

Intergroup comparison indicated that the ultrasound group showed superior efficacy over the RF group in the mid-face (Z = 2.915, p = 0.004) and lower face (Z = 2.142, p = 0.046) on T1. Intragroup comparison observed a statistically significant reduction in FLR and MFWS scores with both treatments. Subjective satisfaction aligned with objective results, and no severe adverse reactions were observed.

Both RF and FU are effective in facial rejuvenation, though their efficacy differs. They are comparably safe and yield high patient satisfaction.

ChiCTR number: ChiCTR2500097849.