Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.2K
The Thyroid Gland01:23

The Thyroid Gland

4.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.3K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

683
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
683
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

48
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
48
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

20
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

British Thyroid Association Survey of Graves' Disease Management in the UK.

Clinical endocrinology·2025
Same author

Conservatively managed non-functioning pituitary macroadenomas-cohort study from the UK Non-functioning Pituitary Adenoma Consortium.

European journal of endocrinology·2025
Same author

Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR).

Clinical endocrinology·2024
Same author

Creating a SNOMED CT reference set for common endocrine disorders based on routine clinic correspondence.

Clinical endocrinology·2023
Same author

Natural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.

European journal of endocrinology·2023
Same author

Adrenal nodules for the non-specialist: What to look out for and when to refer.

The journal of the Royal College of Physicians of Edinburgh·2022

Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

968

Subclinical hyperthyroidism.

Alasdair Cooper1, Prakash Abraham2

  • 1Speciality Registrar in Endocrinology and Diabetes mellitus.

Current Opinion in Endocrinology, Diabetes, and Obesity
|August 20, 2025
PubMed
Summary
This summary is machine-generated.

Subclinical hyperthyroidism, characterized by low thyroid-stimulating hormone (TSH), is linked to atrial fibrillation, osteoporosis, and dementia. Managing this condition requires considering TSH levels and potential risks.

Keywords:
cardiovascular outcomesmortalityneurological outcomessubclinical hyperthyroidismthyroid-stimulating hormone

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

25.7K

Related Experiment Videos

Last Updated: Sep 10, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

968
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

25.7K

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Geriatrics

Background:

  • Subclinical hyperthyroidism involves suppressed thyroid-stimulating hormone (TSH) with normal thyroid hormone levels.
  • While cardiovascular risks like atrial fibrillation are known, effects on other organs are less understood.
  • Recent literature review addresses management uncertainties and expands on known associations.

Purpose of the Study:

  • To review recent literature (last 18 months) on subclinical hyperthyroidism.
  • To clarify associations with cardiovascular and other organ system complications.
  • To inform management strategies for subclinical hyperthyroidism.

Main Methods:

  • Literature review of studies published within the last 18 months.
  • Analysis of meta-analyses on prevalence and risk associations.
  • Inclusion of data from a recent randomized controlled trial.

Main Results:

  • Prevalence data align with previous findings; genetic factors may influence TSH reference ranges, potentially causing misdiagnosis.
  • Stronger evidence links subclinical hyperthyroidism to atrial fibrillation, osteoporosis, and fractures.
  • Emerging data suggest an association with dementia; treatment normalization of TSH reduced atrial fibrillation risk.

Conclusions:

  • The degree of TSH suppression is critical for clinical assessment.
  • Subclinical hyperthyroidism is associated with increased risks of atrial fibrillation, osteoporosis, and dementia.
  • Further research is essential to fully understand and manage this condition.