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Halophyte decocted extract alleviates metabolic and histopathological disturbances induced in human-like rodent
Yosr Z Haffani1, Souhaieb Chrigui1, Ramla Khiari1,2
1Laboratory of Physiopathology, Food and Biomolecules, Higher Institute of Biotechnology Sidi Thabet, BiotechPole, Sidi Thabet, Tunisia.
Background:
The effect of halophyte plant "Salicornia arabica" decocted extract (HDE) on histological damage and metabolic disorders induced by a High-Caloric Diet (HCD) in Psammomys obesus (P. obesus) was investigated.
Methods:
Forty P. obesus were divided into two groups: receiving a natural Low-Caloric Diet (LCD) or a high-caloric diet (HCD). On day 90, each group was further subdivided into two groups, with or without a daily oral administration of HDE at 300 mg/kg body weight for one month. Body weight, glycaemia, and serum lipid profile were assessed. Histopathological analyses on retinal, pancreatic, renal, and adipose tissues were conducted on day 120.
Results:
HDE administration markedly alleviates the HCD-induced metabolic disorder and histopathological alterations, restoring tissue integrity compared to the untreated HCD group. ATR-FTIR and micronutrient analyses showed HDE contains antioxidant minerals, soluble dietary fibers, and phenolic compounds likely responsible for its effects.
Conclusion:
HDE may protect against HCD-induced metabolic disorders and tissues alteration in P. obesus.
