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Updated: Sep 10, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Gliptin-induced Pemphigus
Avinash Jadhav1, Sandra Arora, Ashwini Dattatray Mundhe
1Department of Dermatology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.
Abstract:
This case highlights the development of gliptin-induced pemphigus in a patient shortly after initiating gliptin therapy for diabetes. It is essential to differentiate drug-induced pemphigus from idiopathic cases, as they can be clinically and histopathologically indistinguishable. A detailed medical history, including medication use, is crucial to identifying drug-induced conditions. The time interval between initiating the suspected drug and the onset of skin manifestations can vary widely from case to case. Improvement of the lesions following drug cessation confirms the diagnosis of drug-induced pemphigus.
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