Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin condition in which reactive oxygen species (ROS) contribute to its pathogenesis. Hydrogen water (HW), with potent antioxidant properties, may counteract ROS and improve AD symptoms. This study assessed the clinical efficacy of nano-HW wet-wrap dressing in AD.

Twenty AD patients received wet-wrap therapy using sterile gauze soaked in nano-bubble HW. In eight patients, a split-body design was used: one limb with nano-HW, the other with pure water.

HW wet-wrap significantly reduced erythema (0.5 ± 0.69, p = .01), dryness (0.7 ± 0.57, p = .002), and total score (1.55 ± 1.64, p < .0001), while pure water showed no significant changes. HW-treated limbs improved more than pure water-treated limbs.

HW wet-wrap therapy is a safe, effective adjunct for pediatric AD, improving erythema, dryness, and hydration while limiting systemic side effects.