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Retraction Note: Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent

Mona F Mahmoud1, Shimaa M El Shazly2, Waleed Barakat2

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. mona_pharmacology@yahoo.com.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|August 20, 2025
PubMed
Abstract

No abstract available in PubMed .

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NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...