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Updated: May 2, 2026

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
Multifunctional Nanoplatform Combining Photothermal Therapy and Chemoimmunotherapy for the Treatment of Escherichia
Maolin Li1, Yin Liu2, Dandan Han1,3
1State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, P. R. China.
Abstract:
The presence of bacteria in colorectal cancer not only induces drug inactivation but also inhibits the antitumor immune responses. Here, a multifunctional nanoplatform (IR/CP@BNP@HA) is designed to enhance antitumor photothermal therapy and chemoimmunotherapy for the treatment of bacterium-infected tumors. IR/CP@BNP@HA consists of the hyaluronic acid (HA) shell and reactive oxygen species (ROS)-responsive chitosan biguanide-functionalized biopolymer core (IR/CP@BNP), which encapsulates chemotherapy drug camptothecin (CPT) and photothermal agent IR1048. IR/CP@BNP@HA actively targeted the tumor and was subsequently degraded by abundant hyaluronidase (HAase) present in the extracellular matrix. The resultant IR/CP@BNP exhibited a size decrease and charge reversal, which facilitated a deep tumor penetration. After internalization, the exposed guanidine group of IR/CP@BNP effectively eliminated intracellular bacteria and accomplished lysosome escape. Additionally, intracellular ROS induced the precise release of drugs. More importantly, IR/CP@BNP@HA also promoted dendritic cell maturation, which in turn facilitated T-cell infiltration and maximized the antitumor immune response.
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