Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.0K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.4K
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

10.0K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
10.0K
Abnormal Proliferation02:23

Abnormal Proliferation

4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the First Graft: Skin Cancer Risk and Risk Stratification in Retransplanted Solid Organ Recipients.

The British journal of dermatology·2026
Same author

Growing Into Adult Care: Practical Pearls for Transition in Allergy and Immunology.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Squamoid Eccrine Ductal Carcinoma: Case Series of a Rare, Potentially Aggressive Skin Cancer Associated With Immunosuppression.

Journal of cutaneous pathology·2026
Same author

Self-management for youth and young adults with childhood-onset chronic conditions: A scoping review of health care transition planning literature.

Health care transitions·2026
Same author

Vitamin D receptor <i>BsmI</i> haplotype <i>BB</i> confers lower 25(OH)D levels during tuberculosis: a pilot cross-sectional study.

Therapeutic advances in infectious disease·2026
Same author

Towards tailored and patient-centred care for lentigo maligna.

Clinical and experimental dermatology·2026

Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K

Vulval squamous cell carcinoma: a review.

Charlotte Sheern1, Nick J Levell1,2, Paul J Craig3

  • 1Norwich Medical School, University of East Anglia, Norwich, UK.

Clinical and Experimental Dermatology
|August 20, 2025
PubMed
Summary

Vulval squamous cell carcinoma (VSCC) is rising globally, with two main causes: human papillomavirus (HPV) infection and chronic inflammation. Early diagnosis and treatment are crucial for better survival rates.

More Related Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.6K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

528

Related Experiment Videos

Last Updated: Sep 10, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.6K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

528

Area of Science:

  • Oncology
  • Gynaecology
  • Dermatology

Background:

  • Vulval squamous cell carcinoma (VSCC) accounts for 90% of vulval cancers.
  • Incidence is rising globally, with highest rates in Western Europe, North America, and Northern Europe.
  • Two distinct etiological pathways exist: HPV-dependent and HPV-independent.

Purpose of the Study:

  • To provide a comprehensive overview of current evidence on VSCC epidemiology, clinical features, diagnosis, and management.
  • To highlight recent refinements in national guidelines for VSCC.
  • To discuss the impact of the HPV vaccine on VSCC incidence.

Main Methods:

  • Review of current epidemiological and clinical evidence.
  • Analysis of diagnostic workup including clinical history, examination, vulvoscopy, and biopsies.
  • Examination of treatment modalities including surgical excision, chemoradiotherapy, and immunotherapy.

Main Results:

  • VSCC presents with a suspicious vulval lesion, but early symptoms can be non-specific, causing diagnostic delays.
  • Prognosis is stage-dependent, with 5-year survival dropping significantly from early to late stages.
  • The HPV vaccine represents a potential intervention to impact future VSCC incidence.

Conclusions:

  • VSCC pathogenesis involves HPV infection or chronic inflammatory dermatoses.
  • Timely diagnosis and appropriate treatment based on FIGO staging are critical for patient outcomes.
  • The HPV vaccine holds promise for reducing the future incidence of VSCC.