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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Safeguarding Vulnerability: COVID-19's Impact on Immunocompromised Patients With Cancer.

Viviana Cortiana Ms, Maduri Balasubramanian Md, Jade Gambill Bs

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    Immunocompromised patients face severe COVID-19 risks due to reduced vaccine efficacy. New strategies and tailored public health measures are crucial for their protection against the virus.

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    Area of Science:

    • Infectious Diseases
    • Immunology
    • Public Health

    Background:

    • COVID-19 poses severe risks to immunocompromised individuals, even post-vaccination.
    • This population experiences lower vaccine efficacy, prolonged viral shedding, and increased disease severity.

    Purpose of the Study:

    • To review challenges and emerging strategies for managing COVID-19 in immunocompromised patients.
    • To highlight the need for enhanced surveillance and tailored interventions.

    Main Methods:

    • Review of insights from a keynote lecture on COVID-19 in immunocompromised populations.
    • Discussion of current and emerging therapeutic and preventive strategies.
    • Consideration of viral evolution, hybrid immunity, and ethical implications.

    Main Results:

    • Reduced vaccine effectiveness and increased COVID-19 severity are key concerns for immunocompromised patients.
    • Monoclonal antibodies, antivirals, personalized vaccines, and T cell therapies show potential.
    • Within-host viral evolution necessitates genomic surveillance.

    Conclusions:

    • Tailored public health measures, vaccination programs, and lifestyle interventions are essential.
    • Equitable access to preventive and therapeutic strategies requires collaborative efforts.
    • Strengthening healthcare resilience for vulnerable populations is critical.