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Published on: June 18, 2021
Outcomes After Reversible Cerebral Vasoconstriction Syndrome With Convexity Subarachnoid Hemorrhage: Individual
Isabel Charlotte Hostettler1,2,3, Ana Ponciano1, Duncan Wilson1
1Stroke Research Centre, University College London, Institute of Neurology, United Kingdom.
Insights
Patients with convexity subarachnoid hemorrhage (cSAH) due to reversible cerebral vasoconstriction syndrome (RCVS) have a good prognosis. Most patients achieve functional independence with low rates of recurrent vascular events like cSAH, ICH, or ischemic stroke.
Area of Science:
- Neurology
- Vascular Neurology
- Neurocritical Care
Background:
- Convexity subarachnoid hemorrhage (cSAH) in younger patients is often caused by reversible cerebral vasoconstriction syndrome (RCVS).
- Limited data exist on long-term outcomes and functional recovery after RCVS-associated cSAH.
Purpose of the Study:
- To assess the rates of recurrent cSAH, intracerebral hemorrhage (ICH), and ischemic stroke after RCVS-associated cSAH.
- To evaluate functional outcomes and mortality in these patients.
- To identify baseline predictors for these outcomes.
Main Methods:
- Individual patient data from a pooled analysis of 21 eligible cohorts (138 patients) were used.
- Systematic literature search conducted in PubMed and EMBASE.
- Follow-up was truncated at 5 years, with outcomes including recurrent cSAH, ICH, ischemic stroke, mortality, and modified Rankin Score (mRS).
Main Results:
- During a mean follow-up of 1.8 years, annual recurrence rates for cSAH, ICH, and ischemic stroke were all 0.81%.
- Most patients (94.3%) achieved a modified Rankin Score of ≤1, indicating minimal to no disability.
- Two deaths occurred (annual rate 0.5%), both within two months of the initial cSAH event.
Conclusions:
- RCVS-associated cSAH generally has a favorable prognosis with low rates of recurrent vascular events.
- A high proportion of patients achieve functional independence.
- Findings provide valuable prognostic information for clinical practice, despite limitations of retrospective data collection and potential selection bias.
Background And Objectives:
The most common cause of convexity subarachnoid hemorrhage (cSAH) in younger patients (younger than 60 years) is reversible cerebral vasoconstriction syndrome (RCVS). Evidence on the long-term outcomes of future vascular events and functional outcome after cSAH due to RCVS is limited. We aimed to assess the rates and baseline predictors of our primary outcomes (cSAH, intracerebral hemorrhage (ICH), and ischemic stroke), functional outcome, and mortality after cSAH attributed to RCVS.
Methods:
Individual patient data pooled analysis in patients with cSAH attributed to RCVS. A systematic literature search was conducted in PubMed and EMBASE. Two independent reviewers screened studies and extracted data. Quality assessment was assessed using the Newcastle-Ottawa Scale. Early events during the accepted time frame of an RCVS episode (<3 months) were classified as progression rather than recurrence. Follow-up was truncated at 5 years. Primary outcomes were recurrent cSAH, ICH, and ischemic stroke. Secondary outcomes were mortality and functional status measured by modified Rankin Score (mRS).
Results:
We identified 21 eligible cohorts finally including 138 patients from 9 collaborative centers, which provided individual patient data. The mean age was 49.3 ± 12.1 years, and 110 (79.7%) were female. During a mean follow-up of 1.8 years, annual rates were cSAH recurrence 0.81% (95% CI 0.1-2.91), ICH 0.81% (95% CI 0.1-2.91), and ischemic stroke 0.81% (95% CI 0.1-2.91). Progression during the initial episode (shortly after admission) occurred in 10 patients for cSAH, 2 for ICH, and 8 for ischemic stroke, respectively. Of 106 patients (76.8%) with available outcome data, 100 (94.3%) achieve a mRS of ≤1 at follow-up, indicating no significant disability. Two patients died (annual rate 0.5%, 95% CI 0.09-2.9): one within 10 days and the other within 2 months of the cSAH.
Discussion:
Our data suggest a favorable prognosis for most patients after RCVS-associated cSAH with low rates of recurrent events and a high proportion achieving functional independence. Major limitations include retrospective data collection and potential selection bias from centers providing individual patient data. Nevertheless, these findings provide prognostic information to inform clinical practice.
