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Updated: Sep 10, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
One-Pot Multicomponent Synthesis of 2-Amino-3,4,6-triarylpyridine
Haipeng Bai1, Yan-En Wang2, Huan-E Lao1
1State Key Laboratory of Materials Oriented Chemical Engineering (MCE), Technical Institute of Fluorochemistry (TIF), School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China.
Abstract:
2-Aminopyridines represent an important class of heterocyclic compounds due to their broad biological activities and medicinal significance. Herein, we report an efficient transition-metal-free synthesis of 2-aminopyridines from readily available phenylacetonitrile, benzonitrile, and phenylacetylene derivatives mediated by KN(SiMe3)2. This method exhibits a broad substrate scope (49 examples, 14-97% yields) and excellent scalability, highlighting its potential applications in medicinal chemistry. A plausible mechanism for the transformation was demonstrated.
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