Related Experiment Video

Updated: Sep 10, 2025

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

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Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Míriam Martínez-Cartró1,2, Álvaro Serrano-Morrás1,2, Andrea Bertran-Mostazo1,2

  • 1Departament de Farmàcia i Tecnologia Farmacéutica, i Fisicoquímica. Facultat de Farmàcia i Ciències de l'Alimentació Universitat de Barcelona, Barcelona, 08028, Spain.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 20, 2025
PubMed

Keywords:
AllosterismE3 ligasesLigandability/druggabilitydrug discoverytargeted protein degradation

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