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Measurement of the 211At activity via alpha-particles counting with a liquid scintillation spectrometer
Chihiro Shimodan1, Kasumi Arai2, Masataka Imamura2
1National Institute of Advanced Industrial Science and Technology (AIST), National Metrology Institute of Japan, AIST, Tsukuba Central 2, 1-1-1, Umezono, Tsukuba, Ibaraki, Japan.
Abstract:
Alpha-particle emitters have garnered considerable interest as therapeutic radiopharmaceuticals, with 211At emerging as a viable candidate. In this study, the activity concentration of an 211At solution was determined via alpha-particle counting with a liquid scintillation spectrometer. Alpha-particles, in the region of interest set for pulse-height spectral measurement, were counted, and the counts were corrected for alpha-particle counting efficiency determined using 241Am standard source. The uncertainty in the alpha-particle counting efficiency was the largest contributor to the overall uncertainty. This result suggests that the combined uncertainty can be reduced by improving the method for evaluating alpha-particle counting efficiency.
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