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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase...
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From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
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Interphase diffusion in two-phase fluids: local dynamics and finite-size effects.

Quang K Loi1, Debra J Searles2

  • 1Centre for Theoretical and Computational Molecular Science, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.

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|August 20, 2025
PubMed
Summary
This summary is machine-generated.

Finite-size effects significantly impact fluid diffusion at interfaces. Molecular dynamics simulations reveal local variations in diffusion, influenced by interface properties and system size, mimicking nano-confined fluids.

Keywords:
Finite sizeInterfaceLocal diffusionPhase separation

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Area of Science:

  • Physical Chemistry
  • Computational Fluid Dynamics

Background:

  • Diffusion across fluid-fluid interfaces is crucial for industrial separation and biological processes.
  • The local interface structure strongly influences diffusion dynamics.
  • Simulating these systems may exhibit significant finite-size effects due to interface confinement.

Purpose of the Study:

  • To investigate global and local diffusion dynamics at fluid-fluid interfaces.
  • To determine the influence of immiscibility and system size on diffusion.
  • To elucidate the nature of finite-size effects in such systems.

Main Methods:

  • Molecular dynamics simulations were employed.
  • A binary mixture of Lennard-Jones fluids was studied.
  • Varying degrees of immiscibility and system sizes were simulated.

Main Results:

  • Strong local variations in normal and lateral diffusion were observed.
  • Lateral diffusion peaked at the interface; normal diffusion was highest in the unfavorable phase.
  • Finite-size effects on diffusion showed similarities to nano-confined fluids.
  • Hydrodynamic effects, an artifact of cell size, influenced lateral diffusion.

Conclusions:

  • Finite-size effects significantly alter diffusion dynamics at fluid-fluid interfaces.
  • Both species distribution and hydrodynamic artifacts contribute to these effects.
  • The findings provide insights into diffusion in confined and interfacial systems.