Effect of Blue Covarine Toothpastes on Tooth Colour: A Randomised Crossover Study

Area of Science:

• Dental Science
• Cosmetic Dentistry
• Material Science

Background:

• Tooth discoloration and yellowness are common aesthetic concerns.
• Effective and immediate tooth whitening solutions are in demand.
• Covarine compounds are known for their optical properties.

Purpose of the Study:

• To evaluate the efficacy of toothpastes containing blue covarine in enhancing tooth whiteness.
• To measure the reduction in tooth yellowness following the use of specific toothpastes.
• To compare the effects of different blue covarine concentrations and combinations with other ingredients.

Main Methods:

• A randomized, double-blind, 4-period crossover study was conducted with 66 participants.
• Four silica-based fluoride toothpastes were tested: control, blue covarine (BC1), higher blue covarine (BC2), and blue/green covarine with clay/charcoal (BC+GC).
• Tooth color was assessed using a video-digital imaging system, measuring whiteness index (WIO) and yellowness index (YIO) after single brushing.

Main Results:

• All tested toothpastes significantly increased tooth whiteness and decreased yellowness immediately after a single brushing (P < .0001).
• Toothpastes containing blue covarine (BC+GC, BC1, BC2) demonstrated statistically significant improvements in WIO and reductions in YIO compared to the control.
• The BC+GC formulation showed the most pronounced effect, with mean WIO difference of 5.51 ± 0.40 and YIO difference of -4.37 ± 0.34.

Conclusions:

• Toothpastes formulated with blue covarine provide immediate and effective tooth whitening.
• The addition of blue and green covarine, along with clay and charcoal, further enhances the whitening and yellowness reduction effects.
• Single-brushing application of these toothpastes leads to measurable improvements in tooth appearance.