Sulfhydryl group modification of thymidylate synthetase and its effect on activity and ternary complex formation

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

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Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

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Structures of the lipid II flippase from the monoderm pathogen Staphylococcus aureus.

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ZBTB38 requires an extended N-terminal zinc finger network to read mCpG- and discriminate TpG-containing DNA sequences.

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Related Experiment Videos

Sulfhydryl group modification of thymidylate synthetase and its effect on activity and ternary complex formation

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Structures of the lipid II flippase from the monoderm pathogen Staphylococcus aureus.

The black fly salivary protein Simukunin inhibits complement activation through the lectin pathway protease MASP-2.

The BAIAP2 Pathway Regulates Proliferation and Migration in Medulloblastoma.

Targeting PGAM1 Y119 Phosphorylation Resensitizes Non-Small Cell Lung Cancer to Cisplatin Therapy by Promoting Oxidative Stress and DNA Damage.

M6PR/IGF2R double-knockout supplies therapeutic sources for mucolipidosis II and Niemann-Pick C2.

ZBTB38 requires an extended N-terminal zinc finger network to read mCpG- and discriminate TpG-containing DNA sequences.

Target to Non-Target: Exploring Indoxacarb Toxicity and Resistance.

Ailanthone exerts insecticidal activity as a non-orthosteric 20E antagonist by promoting ecdysone receptor degradation.

CRISPR/Cas9-mediated knockout of CsRDL1 decreases the susceptibility of Chilo suppressalis to cyproflanilide.

Gelphyman, a cryptic and novel thermoreversible gelling polysaccharide activated by c-di-GMP in Paraburkholderia phymatum STM815.

Mechanistic Characterization of GedF Reveals a Ser-Tyr Catalytic Core with a Flexible Basic Residue in a Filamentous Fungal Anthraquinone SDR.

Targeted O-GlcNAcylation enables functional rewiring of c-Myc.

Related Experiment Videos

Sulfhydryl group modification of thymidylate synthetase and its effect on activity and ternary complex formation

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