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Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia.

Dan Shuai1, Binyou Wang1, Duanfang Cai1

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Appendicular skeletal muscle mass indexed to waist circumference (ASMIwc) significantly correlates with cognitive function in schizophrenia inpatients. This finding highlights the importance of muscle mass in maintaining cognitive abilities in this population.

Keywords:
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Metabolic Health

Background:

  • Schizophrenia is a chronic mental disorder associated with significant cognitive deficits.
  • Body composition, particularly muscle mass, is increasingly recognized as a factor influencing cognitive function.
  • The relationship between specific appendicular skeletal muscle mass indices and cognitive performance in stable schizophrenia inpatients requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between various appendicular skeletal muscle mass indices (ASMIht, ASMIbmi, ASMIwt, ASMIwc) and cognitive function.
  • To assess the association between muscle mass metrics and cognitive performance using the Montreal Cognitive Assessment-Chinese version (MoCA-C) in stable schizophrenia inpatients.

Main Methods:

  • A cross-sectional study involving 235 stable schizophrenia inpatients.
  • Collection of demographic and body composition data.
  • Utilized the Montreal Cognitive Assessment-Chinese version (MoCA-C) for cognitive assessment.
  • Employed multiple linear regression analyses to determine associations between muscle mass indices and cognitive function.

Main Results:

  • Appendicular skeletal muscle mass indexed to waist circumference (ASMIwc) showed a significant association with MoCA-C scores in males (r=0.323, FDR=0.004).
  • In females, ASMIbmi, ASMIwt, and ASMIwc were all significantly correlated with MoCA-C scores (r=0.268-0.421, FDR <0.05).
  • Covariate-adjusted regression confirmed ASMIwc as the sole significant predictor of MoCA-C scores in both males (β=0.565, p=0.007) and females (β=0.96, p=0.001).

Conclusions:

  • Appendicular skeletal muscle mass indexed to waist circumference (ASMIwc) is substantially correlated with cognitive function in schizophrenia inpatients.
  • These findings suggest that ASMIwc may serve as a relevant indicator of cognitive status in this population.
  • Further validation in diverse populations is warranted to confirm these results.