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Strategies of tea polyphenol-mediated delivery systems based on Mannich reaction for precision nutrition
Yukun Song1, Xiumin Zhang1, Yiping Chen1
1State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian 116034, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China.
Abstract:
Food bioactive compounds are mostly unstable during production, storage, and severe gastrointestinal conditions, limiting their bioavailability and practical application. Therefore, it is necessary to find effective methods to protect the food bioactive compounds from degradation and exert their potential benefits. Functionalized tea polyphenol-mediated delivery systems based on Mannich condensation reactions have been extensively developed and applied as nanocarriers to improve the bioavailability of food bioactive compounds, and exhibit great potential in precision nutrition research and applications. This review focuses on elucidating the development of tea polyphenol-mediated delivery systems including nanoparticles, Pickering emulsion, and hydrogels to enhance the bioavailability of food bioactive compounds. The benefits of tea polyphenol-mediated delivery systems based on Mannich reaction in precision nutrition are reviewed, including enhanced bioavailability, stimulus response release ability and targeted delivery at cellular or organelle levels for disease intervention applications. Finally, challenges and future perspectives related to tea polyphenol-mediated delivery systems for precision nutrition are discussed. The tea polyphenol-mediated delivery systems can improve the stability and bioavailability of food bioactive compounds during digestion and absorption, and meet the diverse requirements of precision nutrition for special populations.
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