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Updated: Sep 10, 2025

Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels
Published on: October 7, 2021
Evaluation of vascular calcification and Vessel Wall in patients with lower extremity artery disease using CT-like
Hidehisa Hatakeyama1, Takayuki Sakai2, Sakuramaru Suzuki3
1Department of Radiology, Eastern Chiba Medical Center, 3-6-2 Okayamadai, Togane, Chiba 2838686, Japan.
Purpose:
Lower extremity artery disease (LEAD), a major manifestation of peripheral arterial disease (PAD), is significantly influenced by vascular calcification, which impacts treatment outcomes. This study evaluates the feasibility of CT-like imaging using 3D multi-echo T2*-weighted image (T2*WI) for assessing vascular calcifications and vessel wall area in patients with LEAD.
Materials And Methods:
A 3.0 T MRI system was used to acquire CT-like images from 20 patients with LEAD (median age: 75.0 years). Vascular calcifications were assessed in 10 patients who had previously undergone non-contrast CT, while vessel wall area was evaluated in another 10 patients using three-dimensional (3D) fat-suppressed T1-weighted turbo spin-echo (FS-T1 TSE).
Results:
CT-like imaging demonstrated moderate agreement with non-contrast CT for the visual assessment of vascular calcifications (κ = 0.75) and a strong correlation for the quantitative evaluation of calcification (r = 0.91-0.96). Bland-Altman analysis showed minimal bias in vessel wall area measurements between CT-like imaging and FS-T1 TSE.
Conclusion:
CT-like imaging is a feasible technique for assessing vascular calcifications and vessel wall area in patients with LEAD. The absence of radiation exposure makes it a promising alternative to CT for vascular evaluation.
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An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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