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Updated: Sep 10, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.0K

Research progress of circular RNA and N6-methyladenosine modification in colorectal cancer

Jiamei Xu1, Jin Liu2, Fengxia Huang2

  • 1Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523710 Guangdong Province, China; Department of Pathology & Department of Pathology Technology, Guangdong Medical University, Dongguan 523808 Guangdong Province, China.

Gene
|August 20, 2025
PubMed

Insights

Circular RNAs (circRNAs) and N6-methyladenosine (m6A) modifications are key players in colorectal cancer (CRC). This review explores their interaction and impact on CRC development and progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • RNA Biology

Background:

  • Circular RNAs (circRNAs) are stable, non-coding RNAs involved in gene regulation.
  • N6-methyladenosine (m6A) is a prevalent RNA modification influencing RNA metabolism.
  • Both circRNAs and m6A are implicated in cancer research, particularly colorectal cancer (CRC).

Purpose of the Study:

  • To review the interplay between circRNAs and m6A modification.
  • To highlight their collective roles in colorectal cancer (CRC) pathogenesis and progression.

Main Methods:

  • Literature review focusing on circRNA and m6A research in CRC.
  • Analysis of studies investigating the regulatory interactions between circRNAs and m6A machinery.
  • Synthesis of current understanding of their combined impact on CRC.

Main Results:

  • CircRNAs exhibit unique properties like stability and conservation, influencing CRC biology.
  • m6A modification dynamically regulates circRNA metabolism (biogenesis, trafficking, turnover).
  • CircRNAs can, in turn, modulate the expression of m6A-related enzymes.

Conclusions:

  • The interaction between circRNAs and m6A modification is a critical factor in CRC.
  • Understanding this interplay offers potential therapeutic targets for colorectal cancer.
Keywords:
BiomarkerCRCCircRNARegulatory functionm6A

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