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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

42
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
42
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

21
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
21
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

52
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
52
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

36
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
36
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

37
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
37
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

39
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
39
  1. Home
  3. Research Domains
  5. Human Society
  7. Gender Studies
  9. Intersectional Studies
  11. Clinical Outcomes In Women And Men With Raphe-type Bicuspid Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Replacement.
  1. Home
  3. Research Domains
  5. Human Society
  7. Gender Studies
  9. Intersectional Studies
  11. Clinical Outcomes In Women And Men With Raphe-type Bicuspid Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Replacement.

Related Experiment Video

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

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Clinical outcomes in women and men with raphe-type bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement.

Mauro Gitto1, Won-Keun Kim2, Andrea Buono3

  • 1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

International Journal of Cardiology
|August 20, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Women undergoing transcatheter aortic valve replacement for bicuspid aortic valve stenosis had lower technical success but similar long-term outcomes compared to men. Prognostic factors differed significantly between sexes.

Keywords:
Bicuspid aortic valveSievers type 1Transcatheter aortic valve replacementVARC-3

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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Aortic Valve Disease

Background:

  • Limited data exists on sex-based differences in patients with bicuspid aortic valve (BAV) undergoing transcatheter aortic valve replacement (TAVR).
  • Understanding these differences is crucial for optimizing TAVR outcomes in diverse patient populations.

Purpose of the Study:

  • To investigate sex-related differences in procedural outcomes and long-term clinical results of TAVR in patients with Sievers type 1 BAV stenosis.
  • To identify sex-specific predictors of major adverse events (MAEs) after TAVR in this population.

Main Methods:

  • Observational, retrospective registry (AD-HOC) including 980 patients with Sievers type 1 BAV stenosis undergoing TAVR.
  • Propensity score adjustment was used to compare outcomes between men and women.
Women
  • Primary endpoint was MAEs (death, neurologic events, heart failure hospitalization) at 3 years.

    • Main Results:

    • Women (37%) had lower technical and device success rates and more periprocedural bleedings compared to men.
    • No significant sex differences were observed in 3-year MAEs.
    • Predictors of MAEs differed: diabetes, COPD, and severe calcifications in men; chronic kidney disease in women.

    Conclusions:

    • Women with raphe-type BAV stenosis undergoing TAVR experience lower procedural success but achieve similar long-term clinical outcomes as men.
    • Sex-specific factors influence MAE prediction, highlighting the need for tailored management strategies in TAVR for BAV.
    • Hemodynamic valve performance and baseline gradients appear to have a protective effect in women.