Related Experiment Video
Updated: Sep 10, 2025
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
The role of thyroid peroxidase gene variant rs2175977 in subclinical hypothyroidism and autoimmune thyroid response
Larsa Naji Adam1, Awat Mustafa Abbas1
1Department of Biology, College of Science, University of Zakho, Duhok, Kurdistan Region, Iraq; Biology Research Center, Research Center, University of Zakho, Duhok, Iraq.
Aim:
Study investigated the association of the thyroid peroxidase (TPO) gene polymorphism with Subclinical hypothyroidism (SCH) risk.
Methods:
A case-control study of 78 SCH patients SCH and 75 controls. Genomic DNA extracted from the blood, and the rs2175977 SNP in the Exon 8 of the TPO gene was genotyped through the PCR and Subsequent RFLP by SgrBI digestion. Statistics assessed genotype frequencies, allelic distributions, and associations with biochemical parameters.
Results:
The GG genotype was significantly more in controls compared to SCH patients (p = 0.0039), while GC and CC genotypes were more prevalent in SCH. The C allele was significantly associated with increased SCH risk (p = 0.0006; OR = 0.3887). The GC and CC variant had significantly higher levels of Anti-TPO antibodies (p = 0.0429).
Conclusion:
A TPO gene polymorphism, has been linked to increased risk of SCH and an elevated level of anti-TPO antibodies, indicating thyroid autoimmune disorder.
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
01:18Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:23The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
01:39Epistasis