Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

979

Sodium glucose cotransporter 2 inhibitor use after heart transplant: Current knowledge and potential applications

Lisa M Raven1, Lina Brinker2, Konstantinos Sideris2

  • 1Department of Diabetes and Endocrinology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia; School of Clinical Medicine, St Vincent's Campus, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|August 20, 2025
PubMed

Insights

Sodium glucose cotransporter 2 inhibitors (SGLT2i) show promise for heart transplant (HTx) recipients. These drugs may improve cardiovascular, kidney, and metabolic health, addressing key long-term complications post-transplant.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Heart transplant (HTx) improves survival for end-stage heart failure but long-term outcomes are limited by comorbidities.
  • Comorbidities like cardiovascular, kidney, and metabolic diseases pose significant risks post-HTx.
  • Transplant recipients are often excluded from clinical trials, limiting evidence for beneficial treatments.

Purpose of the Study:

  • To review the potential benefits of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) in heart transplant recipients.
  • To explore the mechanistic pathways through which SGLT2i may mitigate post-HTx morbidities.
  • To summarize existing experimental and retrospective data and highlight the need for prospective trials.

Main Methods:

  • Review of mechanistic rationale for SGLT2i use in HTx recipients.
  • Summary of experimental studies on SGLT2i in reversing calcineurin inhibitor-induced injury.
  • Analysis of retrospective studies assessing SGLT2i effects in HTx patients.

Main Results:

  • SGLT2i possess renoprotective, glycemic, vascular, anti-inflammatory, and erythropoietic effects.
  • Experimental studies show SGLT2i can reverse calcineurin inhibitor-associated kidney and pancreatic injury.
  • Retrospective studies indicate SGLT2i improve glycemia, weight, and renal function in HTx recipients.

Conclusions:

  • SGLT2i offer potential benefits for managing long-term complications in heart transplant recipients.
  • Further prospective clinical trials are essential to confirm the efficacy and safety of SGLT2i in this population.
  • Ongoing registered trials are crucial for advancing evidence-based care for HTx survivors.

Keywords:
SGLT2heart transplantationsodium glucose cotransporter 2 inhibitor

More Related Videos

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft08:30

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

2.8K
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

7.9K

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
75
Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
123.7K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
81
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
24.1K
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
32.4K