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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Skin Cancer01:30

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Chronic Bowel Disorders: Introduction01:17

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Personality Disorders: Paranoid and Schizoid01:22

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Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
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Desmosomes01:05

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Updated: Sep 10, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis and Papulosquamous Disorders.

Matthew F Helm1, Karl T Clebak2, Laura Critchfield2

  • 1Department of Dermatology, Penn State Hershey Medical Center, 500 University Drive HU14, Hershey, PA 17033, USA.

Primary Care
|August 20, 2025
PubMed
Summary
This summary is machine-generated.

Psoriasis is a chronic inflammatory skin condition affecting 3% of Americans, influenced by genetics and environment. Management ranges from lifestyle changes and topical treatments to systemic therapies for severe cases.

Keywords:
Papulosquamous disordersPityriasis roseaPityriasis rubra pilarisPsoriasisPsoriatic arthritisSeborrheic dermatitis

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Psoriasis is a chronic, inflammatory skin disease impacting patient quality of life.
  • It affects approximately 3% of the US population.
  • The condition arises from a complex interplay of genetic predisposition and environmental factors.

Purpose of the Study:

  • To provide an overview of psoriasis, its prevalence, etiology, and management strategies.
  • To outline current therapeutic approaches for managing psoriasis.

Main Methods:

  • Review of existing literature on psoriasis epidemiology, pathogenesis, and treatment.
  • Categorization of treatments based on disease severity.

Main Results:

  • Psoriasis exhibits significant prevalence and impacts quality of life.
  • Management strategies are tailored to disease severity, ranging from conservative measures to advanced systemic treatments.

Conclusions:

  • Psoriasis requires a multifaceted management approach.
  • Therapeutic options include lifestyle modifications, topical agents, and systemic therapies (oral or biologic) for more severe presentations.