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Testing Water Quality01:14

Testing Water Quality

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When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
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Data Validation01:15

Data Validation

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Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
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[Validation Study on the Developed Method for Cyanide in Various Mineral Waters].

Hiroshi Sakuragi1, Masako Suzuki1, Hiroyuki Ohno1

  • 1Nagoya City Public Health Research Institute.

Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
|August 20, 2025
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Summary
This summary is machine-generated.

A new method accurately determines cyanide ion and cyanogen chloride in mineral waters. Dilution with phosphate buffer improved pH adjustment, ensuring reliable results for these water contaminants.

Keywords:
cyanide ioncyanogen chlorideion chromatographymineral watervalidation

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Area of Science:

  • Environmental Chemistry
  • Analytical Chemistry

Background:

  • Mineral waters (MWs) present unique challenges for cyanide analysis due to variations in hardness and carbonation.
  • Existing official methods for tap water cyanide analysis may not be suitable for MWs, failing validation criteria in Japan.
  • Pretreatment pH adjustment to approximately 2.4, crucial for accurate cyanide determination, is often unachievable in certain MWs.

Purpose of the Study:

  • To develop and validate a reliable method for determining cyanide ion and cyanogen chloride in diverse mineral waters.
  • To address the limitations of existing methods in accurately analyzing cyanide in mineral water matrices.

Main Methods:

  • A method was developed and validated for the simultaneous determination of cyanide ion and cyanogen chloride.
  • A five-fold dilution step using a phosphate buffer was introduced during sample pretreatment to achieve the target pH of 2.4.
  • Validation was performed according to established guidelines, assessing trueness and precision (RSD).

Main Results:

  • The developed method demonstrated improved trueness, ranging from 93.0% to 103.8%, after incorporating the dilution step.
  • Repeatability and within-laboratory reproducibility (RSD) were below 3.83% and 4.68%, respectively, meeting validation criteria for both analytes.
  • The method successfully achieved the target pH of 2.4 in previously problematic MW samples.

Conclusions:

  • The developed method, including a phosphate buffer dilution step, enables accurate determination of cyanide ion and cyanogen chloride in various mineral waters.
  • This approach overcomes pretreatment pH adjustment challenges, ensuring reliable analytical results for mineral water quality assessment.
  • The validated method shows applicability for routine analysis of these cyanide species in commercial mineral water products.