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Efficacy and Safety of Dotinurad in Patients with Advanced Chronic Kidney Disease

Teppei Motomura1, Mayuka Higashi1, Akihisa Hattori1

  • 1Department of Nephrology, Ibaraki Prefectural Central Hospital, Ibaraki Cancer Center, Japan.

Internal Medicine (Tokyo, Japan)
|August 20, 2025
PubMed

Insights

Dotinurad effectively lowers serum uric acid in patients with advanced chronic kidney disease (CKD). This uricosuric drug demonstrated a safe profile without impacting renal function in the study group.

Area of Science:

  • Nephrology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Hyperuricemia is a known risk factor for cardiovascular disease and chronic kidney disease (CKD).
  • Limited data exists on the efficacy and safety of dotinurad, a uricosuric agent, in patients with advanced CKD (stages G3b-G5).
  • Evaluating dotinurad's impact on serum uric acid and renal function in this population is crucial.

Purpose of the Study:

  • To assess the efficacy of dotinurad in reducing serum uric acid levels in hyperuricemic patients with advanced CKD.
  • To evaluate the safety profile of dotinurad in this patient cohort.
  • To determine the effect of dotinurad on renal function, specifically estimated glomerular filtration rate (eGFR).

Main Methods:

  • A single-center, retrospective observational study.
  • Fourteen patients with CKD G3b-G5 receiving dotinurad were analyzed.
  • Serum uric acid and eGFR were measured six months before and after treatment initiation.

Main Results:

  • Serum uric acid levels significantly decreased from 8.2 mg/dL to 6.2 mg/dL after six months of dotinurad treatment (p<0.01).
  • No significant changes were observed in the estimated glomerular filtration rate (eGFR) during the study period.
  • No adverse events were reported, indicating a favorable safety profile.

Conclusions:

  • Dotinurad is effective in lowering serum uric acid levels in patients with advanced CKD (G3b-G5).
  • The drug appears to be safe for use in this population.
  • Dotinurad did not adversely affect renal function as measured by eGFR.

Keywords:
chronic kidney diseasedotinuradhyperuricemia

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