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The Relationship Between Subjective Cognitive Decline and Objective Cognitive Performance in Older Adults With
Kayla Conaty1, Swathi Gujral2, Erin McCarty3
1Western Psychiatric Hospital (KC, ER), University of Pittsburgh Medical Center, Pittsburgh, PA.
Objectives:
Examine the role of depression severity in linking subjective and objective indicators of cognitive decline.
Methods:
354 participants (60+) were drawn from a multicenter longitudinal neuroimaging and neurocognitive study of TRLLD (the "OPTIMUM-NEURO" study). Subjective cognitive decline (SCD) was assessed using the everyday cognition scale. Objective cognitive performance (OCP) was assessed using the Repeatable Battery for Neuropsychological Status and subtests of the Delis-Kaplan Executive Functioning System. Depression severity was assessed using the clinician-administered Montgomery-Asberg Depression Rating Scale. Statistical analysis involved demographic-adjusted linear regression models and causal mediation analysis.
Results:
Participant and study partner-reported SCD were associated with OCP in a broad range of cognitive domains. Greater depression severity was related to worse SCD and OCP but did not statistically mediate any SCD-OCP relationships.
Conclusions:
Among individuals with TRLLD, higher SCD is related to greater depression severity; however, SCD and depression severity each independently relate to OCP.
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