Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients
Jia Mai1, Ling Yang1, YuXin Chen1
1Department of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, No. 20, Section 3, Ren Min Nan Lu, Chengdu, 610041, Sichuan, China.
Abstract:
The tumor microenvironment (TME), particularly CD8+ T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8+ T cells. Identifying non-invasive predictors of TME immune status is crucial. We investigated whether clinicopathologic characteristics and peripheral blood parameters could predict CD8+ T infiltration in TME of HGSOC. Two independent cohort were analyzed: (1) A multicenter tissue microarray (TMA) cohort of 105 epithelial ovarian cancer cases revealed that high CD8+ T cell density in tumor parenchyma, stroma, or whole tissue was significantly associated with good prognosis. (2) A retrospective cohort of 95 HGSOC patients from West China Second University Hospital (2016-2020) demonstrated that peripheral blood lymphocytes, globulin (GLB), lactate dehydrogenase (LDH), and low-density lipoprotein (LDL) correlated with CD8+ T cell infiltration in TME. These findings support non-invasive blood markers as predictors of tumor immune status and highlight chemotherapy's role in enhancing CD8+ T cell recruitment.
