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Updated: Sep 10, 2025

Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast

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Published on: November 28, 2018

A fluorescent-protein spin qubit.

Jacob S Feder¹, Benjamin S Soloway¹, Shreya Verma²

¹Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.

|August 20, 2025

Summary

This summary is machine-generated.

Researchers developed a new quantum bit (qubit) using enhanced yellow fluorescent protein. This biological qubit allows for optical control and readout, demonstrating potential for nanoscale sensing in living cells.

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Area of Science:

Quantum Information Science
Biophysics
Molecular Biology

Background:

Optically addressable spin qubits are crucial for nanoscale sensing, primarily engineered in solid-state systems.
Fluorescent proteins are widely used in vivo microscopy due to genetic encodability, but their potential as qubits remains unexplored.
Fluorescent proteins possess a metastable triplet state, a key characteristic for qubit functionality.

Purpose of the Study:

To engineer and characterize an optically addressable spin qubit within a fluorescent protein.
To investigate the feasibility of using fluorescent proteins as a platform for quantum information processing.
To demonstrate the functionality of these biological qubits in complex biological environments.

Main Methods:

Realization of an optically addressable spin qubit in enhanced yellow fluorescent protein.
Utilizing near-infrared laser pulses for triggered readout of the triplet state.
Employing coherent microwave control and Carr-Purcell-Meiboom-Gill decoupling for coherence time measurements at liquid-nitrogen temperatures.
Expressing the qubit in mammalian and bacterial cells to assess performance in vivo.

Main Results:

Achieved triggered readout of the enhanced yellow fluorescent protein spin qubit with up to 20% spin contrast.
Measured a coherence time of (16 ± 2) μs at liquid-nitrogen temperatures.
Demonstrated sustained qubit contrast and coherent control within mammalian cells.
Observed optically detected magnetic resonance in bacterial cells at room temperature with up to 8% contrast.

Conclusions:

Fluorescent proteins represent a novel and powerful platform for creating optical spin qubits.
This biological qubit technology opens avenues for life science applications, including nanoscale sensing and spin-based imaging.
The ability to engineer qubits within genetically encoded fluorescent proteins offers significant advantages for in vivo quantum applications.