Related Experiment Video
Updated: Sep 10, 2025
Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
Published on: June 6, 2025
Novel Biopsy Gun Impacts Biopsy Sample Quality and Quantity
Laetitia Saccenti1,2, Tabea Borde3, Nicole A Varble3,4
1Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA. Laetitia.saccenti@nih.gov.
Purpose:
A biopsy gun featuring alternated serrated cutting edges was designed to improve core stability and tissue acquisition. This study aimed to assess the impact upon core biopsy tissue quantity and quality of a serrated core gun (SUREcore prime, Uro-1).
Materials And Methods:
18G serrated core gun was compared with 18G conventional gun (Maxcore, Becton Dickinson), in both ex vivo (bovine liver, N = 30) and in vivo (swine liver and kidney, N = 24) models. Cores were assessed for weight, length, surface area, fragmentation, and solidity using digital pathology.
Results:
The serrated core gun produced cores with 16% higher median weight (6.60 g vs. 5.70 g, p < 0.001), 10% longer length (11.1 mm vs. 10.1 mm, p = 0.042), and 16% greater surface area (7.80mm2 vs. 6.70mm2, p = 0.024). Fragmentation and solidity did not differ significantly. Subgroup analyses confirmed higher tissue weight across all organs and test conditions. No hemorrhagic complication was observed on post-procedural CT or autopsy.
Conclusion:
The serrated-edge design may improve biopsy sample quality and quantity without increasing needle size or penetration depth, potentially reducing the need for repeated passes. Device research and innovations may further improve biopsy efficacy and outcomes and reduce complications.
