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Novel Biopsy Gun Impacts Biopsy Sample Quality and Quantity
Laetitia Saccenti1,2, Tabea Borde3, Nicole A Varble3,4
1Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA. Laetitia.saccenti@nih.gov.
Cardiovascular and Interventional Radiology
|August 20, 2025
Summary
A novel serrated core biopsy gun significantly increased tissue sample weight, length, and surface area compared to conventional guns. This improved biopsy gun design enhances tissue acquisition without increasing needle size, potentially reducing repeat procedures.
Area of Science:
- Medical Devices
- Surgical Technology
- Pathology
Background:
- Core biopsy is crucial for tissue diagnosis.
- Improving tissue acquisition quantity and quality is essential for accurate diagnosis.
- Current biopsy devices may have limitations in tissue yield and sample integrity.
Purpose of the Study:
- To evaluate the efficacy of a novel serrated-edge core biopsy gun.
- To compare tissue acquisition metrics of a serrated core gun against a conventional gun.
- To assess the impact of serrated design on biopsy sample quantity and quality.
Main Methods:
- A 18G serrated core gun was compared with a 18G conventional core gun.
- Ex vivo (bovine liver) and in vivo (swine liver and kidney) models were used.
- Biopsy cores were analyzed for weight, length, surface area, fragmentation, and solidity using digital pathology.
Main Results:
- The serrated core gun yielded significantly higher median weight (+16%), length (+10%), and surface area (+16%) compared to the conventional gun.
- No significant differences were observed in core fragmentation or solidity.
- Higher tissue weight was consistent across all organs and test conditions, with no observed hemorrhagic complications.
Conclusions:
- The serrated-edge design of the biopsy gun enhances tissue sample quantity and quality.
- This innovation may improve biopsy efficacy and reduce the need for repeat procedures without increasing needle gauge or depth.
- Further research into biopsy device innovations holds promise for improved patient outcomes and reduced complications.
