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Declined intrinsic capacity is associated with one-year functional disability in older hypertensive inpatients

Xingkun Zeng1, Huilan Guan1, Yanyan Wang2

  • 1Department of Geriatrics, Zhejiang Hospital, No 12, Lingyin Road, Hangzhou, 310013, People's Republic of China.

BMC Geriatrics
|August 21, 2025
PubMed

Insights

Declined intrinsic capacity, particularly cognition and locomotion, significantly increases functional disability risk in older hypertensive patients. Early intervention for intrinsic capacity decline is crucial for this population.

Area of Science:

  • Gerontology
  • Cardiology
  • Public Health

Background:

  • Hypertension is a growing global health concern, especially among older adults, increasing cardiovascular disease (CVD) risk.
  • Functional disability in older adults is a significant contributor to mortality and morbidity worldwide.
  • Intrinsic capacity (IC) decline is a key factor in the functional decline of older individuals.

Purpose of the Study:

  • To assess the impact of diminished intrinsic capacity (IC) on the risk of developing functional disability within one year.
  • To investigate the relationship between specific domains of IC and the onset of functional disability in elderly hypertensive patients.

Main Methods:

  • A retrospective observational study included 233 elderly hypertensive patients.
  • Five domains of IC (cognition, locomotion, vitality, psychology, sensory) were evaluated at admission.
  • Functional disability was determined by new dependencies in activities of daily living (ADL) over a 1-year follow-up, analyzed using multivariate logistic regression.

Main Results:

  • Incidence of IC decline varied across domains, with locomotion (55.8%) and sensory capacity (63.1%) showing high rates.
  • Higher IC composite scores correlated with a reduced risk of 1-year functional disability (OR=0.57, P=0.001).
  • Cognitive decline (OR=3.08, P=0.005) and locomotion impairment (OR=3.35, P=0.012) were significant predictors of 1-year functional disability.

Conclusions:

  • Reduced cognitive and locomotion abilities are key predictors of functional disability in hypertensive elderly patients one year post-discharge.
  • Proactive management and prevention strategies targeting intrinsic capacity decline are essential for hypertensive older adults.
Abstract

Keywords:
Functional disabilityHypertensionIntrinsic capacityOlder adults

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